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Mayo Clinic scientists in laboratory

The Clinician-Investigator Training Program incorporates two to three years of uninterrupted research training into a Mayo Clinic residency or fellowship.

At Mayo Clinic, the Clinician-Investigator Training Program provides additional time to dedicate to research training. The program is specifically designed this way to prepare trainees to serve as leaders in academic medicine, surgery and other disciplines.

Training in this program occurs principally under the mentorship of a Mayo Clinic investigator selected by the trainee. Hundreds of mentors are available from the research faculty at Mayo Clinic.

The central aim of this program is to train physician-scientists who will lead successful, extramurally funded research programs and contribute to advances in biomedical research. The Clinician-Investigator Training Program reflects the commitment by Mayo Clinic to foster the investigative careers of individuals dedicated to biomedical and translational research.


Mayo Clinic's unique culture of collaboration and teamwork and its extensive facilities and resources make it possible for researchers to unravel and solve complex research questions. As a trainee in the Clinician-Investigator Training Program, you have an opportunity to be an active member of Mayo Clinic's research team. Specific research training during the program is geared to your interests and career goals.

See Research at Mayo Clinic for more details.

For Internal Medicine residents

For Internal Medicine trainees, the Clinician-Investigator Training Program integrates rigorous clinical training in internal medicine and subspecialty training along with training in research. The Clinician-Investigator Training Program in Internal Medicine is two to three years in duration.

Internal Medicine match track

Medical students (M.D. students and M.D.-Ph.D. students) and international medical graduates who apply through the National Resident Matching Program process for a research track in internal medicine and match into the clinician-investigator track are considered for three types of training in this integrated program.

  1. Residency training in internal medicine of two to three years, depending on the type of clinician-investigator research track (for example, American Board of Internal Medicine-type pathway)
  2. Research training of two to three years that can begin during residency and continue for a period of time prior to entering a subspecialty fellowship
  3. Subspecialty fellowship training (length depends on subspecialty)

For this track, three positions are available annually.

PGY-2 Internal Medicine track

This track provides an opportunity for research training for individuals who decide to pursue research later in their careers — that is, the decision for such training is made during the residency rather than during medical school.

Therefore, residents apply for this track in the fall of their PGY-2 year for a two-year clinician-investigator-supported research appointment in the subspecialty of their choice. This clinician-investigator research training begins at the end of the PGY-3 year in internal medicine and before the commencement of the clinical subspecialty fellowship training.

There are two positions available for this track annually.

For residents in other specialties

In all other postgraduate training specialty and subspecialty training programs besides internal medicine, residents can apply to the Clinician-Investigator Training Program typically during the second year of their clinical training program.

There are four positions available for this track annually.

Didactic training

Educational activities offered throughout Mayo Clinic's Clinician-Investigator Training Program include:

  • Clinician-investigator seminar. Clinician-investigator trainees, assisted by a mentor or an adviser, organize and present an interactive seminar integrating basic science with clinical medicine. A discussion panel of Mayo Clinic staff clinician-investigators also participates in the seminar.
  • CI journal club. This monthly research journal club consists of alternating presentations of work-in-progress by CI trainees, presentation of selected research articles by CI trainees, and meet-the-professor presentations that feature distinguished physician-scientists from Mayo faculty. The journal club is designed specifically to foster interaction among trainees and for trainees to meet successful physicians in an informal setting to discuss career paths and ingredients for success as a physician-scientist.
  • Divisional/departmental research seminars. During the two-year research block, trainees attend and participate in journal clubs, tutorials, courses and seminar series organized by the departments in which they are assigned.
  • Mayo Clinic Graduate School of Biomedical Sciences courses. Trainees are encouraged to select Mayo Clinic Graduate School of Biomedical Sciences courses of direct relevance to their training that the Clinician-Investigator Training Program supports but does not fund. Graduate courses are available in these programs:
    • Biochemistry and structural biology
    • Cell biology and genetics
    • Biomedical engineering
    • Immunology
    • Molecular neuroscience
    • Molecular pharmacology and experimental therapeutics
    • Tumor biology
    • Virology and gene therapy
Mayo Clinic scientists in laboratory

Invited speakers

Clinician-investigator trainees have frequent opportunities to attend and interact with invited speakers prominent in the field of academic medicine. The interaction provides opportunities to learn from role-model academicians and build relationships with national leaders in academic medicine.


As a trainee in this program, your performance and progress is evaluated carefully throughout the program to ensure you acquire adequate knowledge and develop technical skills.

Career planning

You meet periodically with the program director, your supervising mentor and a faculty member to discuss the program and your career goals. Mayo Clinic recruits many staff physicians from its own training programs. Career opportunities may be available at Mayo Clinic in Arizona, Florida and Minnesota.