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M.D. Program

Prerequisites and Requirements

M.D. Students performing an exam in simulation lab during curriculum rotations.

Before you apply to the M.D. Program at Mayo Clinic Alix School of Medicine, review our full list of prerequisite information and complete admission requirements. We value the many unique attributes of our applicants and look forward to reviewing your application.

After you review the prerequisites and general requirements for admission, visit our Admissions and Application Process page to learn more about next steps and to apply. 


Course requirements

All applicants must have the below prerequisite courses completed by June 15 of the planned matriculation year. All required coursework must be completed for a letter grade. Pass/fail or credit/no credit courses will not be accepted.

The only course that is accepted as an online course is biochemistry. All others need to be completed in-person.

AreaMinimum requirement
Biology and/or zoology One year (with one year of lab)
Inorganic chemistry One year (with one year of lab)
Organic chemistry One year (with one year of lab)
Physics One year (with one year of lab)
Biochemistry One course (online course accepted)


Except as defined in the next paragraph, applicants must be a citizen or lawful permanent resident of the United States, a noncitizen national of the United States, Asylee, or Refugee at the time of application.

Foreign nationals regardless of immigration status, who do not fit into the categories listed above, are currently not eligible for admission to Mayo Clinic Alix School of Medicine unless they are able to present, at time of application, proof of eligibility to file the Free Application for Federal Student Aid (FAFSA), or proof of Canadian provincial or federal financial aid support.


All applicants must have a bachelor's or Pharm.D. degree from an accredited college or university in the United States or Canada. A higher degree cannot be substituted for this requirement, and no exceptions will be made.

Medical College Admission Test (MCAT)

The Medical College Admission Test (MCAT) is required of all applicants. Scores must be posted to the AMCAS application no later than Oct. 15 in order to be considered for the current application cycle. Only MCAT scores reported within three years of matriculation year are considered in admissions decisions.

Our current MCAT threshold (latest/most recent MCAT) for admissions consideration is 75th percentile. Applicants with MCAT equal to or greater than 75th percentile will be considered for a secondary application invitation.

Information about this test and the procedures to be followed in reporting scores to medical schools may be obtained through college premedical advisory offices or by contacting:

MCAT Program
P.O. Box 4056
Iowa City, IA 52243-4056
Phone: 319-337-1357

Other admissions requirements

Technical standards (nonacademic criteria)

The M.D. degree is a broad undifferentiated degree attesting to the mastery of general knowledge in all fields required for entry into graduate medical education programs (residencies). Graduates must possess the essential knowledge and skills to function in a broad variety of clinical situations and to render a wide spectrum of patient care safely and effectively.

Mayo Clinic Alix School of Medicine has specified the following nonacademic criteria (technical standards), which all students must meet to participate in the medical education program and the practice of medicine.

Participation and observation

The applicant or medical student must be able to: attend and meaningfully participate in all classroom, small group and laboratory exercises, as well as all clinical experiences throughout the curriculum; interview, assess and comprehend the condition of all patients assigned to him or her for examination, diagnosis and treatment; and access information electronically and utilize technology for learning, such as online modules, web-based learning, simulation and electronic medical records.


The applicant or medical student must be able to communicate effectively and sensitively with patients to elicit information, describe changes in mood, activity and posture, assess nonverbal communication, and transmit information to patients, fellow students, faculty, staff and all members of the health care team.


The applicant or medical student must have sufficient motor function to complete a comprehensive physical examination of patients, including, the ability to elicit information from patients by palpation, auscultation, percussion and other diagnostic maneuvers; possessing all skills necessary to carry out diagnostic procedures; and being able to execute motor movements reasonably required to provide general care and emergency treatment to all patients. The applicant or medical student must be able to order tests and treatments, and document clinical encounters using an electronic medical record.

Intellectual, integrative, and quantitative abilities

The applicant or medical student must be able to measure, calculate, reason, analyze and synthesize. Problem-solving, the critical skill demanded of physicians, requires all of these intellectual abilities. The applicant or medical student must also be able to comprehend 3-D relationships and understand the spatial relationships of structures and have the capacity to perform these problem-solving skills in a timely fashion.

Behavioral attributes

The applicant or medical student must be able to exercise good judgment; promptly complete all responsibilities attendant to the diagnosis and care of patients; and demonstrate mature, sensitive and effective relationships with patients and others.

The applicant or medical student must also be able to tolerate taxing workloads, function effectively under stress, adapt to changing environments, display flexibility, and function in the face of uncertainties inherent in the clinical problems of many patients.

Each applicant or medical student must possess and demonstrate behaviors of professionalism, including compassion, integrity, inclusion, respect and concern for others, commitment, and motivation.

Application requirements

All completed American Medical College Application Service (AMCAS) applications must include:

  • Online AMCAS application
  • Transcripts
  • Application processing/secondary fee
  • Letters of recommendation

For full application requirements, review the Admissions and Application Process page.

Student services pre-matriculation requirements

In order to protect our students, patients, and staff from possible exposures to infectious diseases that are of concern in a health care environment, students are required to provide proof of being fully vaccinated or immune by lab results. Mayo Clinic guidelines are based on the Centers for Disease Control and Prevention (CDC) guidelines.

Accepted and waitlisted learners will receive the required attestation forms as admissions offers begin at Mayo Clinic Alix School of Medicine. Students must submit completed attestation forms signed by an NP/PA/MD/DO as well as copies of immunization records and any applicable lab reports indicating immunity. Full immunity from vaccination takes time, so even if you ultimately choose a different medical school it is recommended you start your immunization review as soon as possible.

If you have questions about these requirements, please review our FAQs or email

Vaccination attestation

Mandatory vaccines with no declination possible

The below vaccines are mandatory with no declination possible. You must have these or your ability to receive these must be determined to be medically contraindicated by your provider.

  • Varicella: Learners are required to have proof of two vaccines or proof of immunity by serology.
  • Measles, Mumps, and Rubella (MMR): Learners are required to have proof of two vaccines or proof of immunity by serology.
  • Tetanus, Diphtheria, Pertussis (Td, Tdap): Learners are required to have a record of a Tdap given at age 11 or later and either vaccine within the past 10 years.

Vaccines with declination possible

The below vaccines are non-mandatory and have declination possible. To be allowed to decline a vaccination for Mayo Clinic purposes, your provider must sign that they counseled you on the risks and benefits of the immunization.

  • Meningitis vaccine: Learners are encouraged to have the age appropriate vaccination for meningitis.
  • Hepatitis B vaccine: Learners must submit proof of immunity by quantitative serology (as opposed to qualitative serology). Please be aware there are two types of lab tests of immunity. Qualitative immunity shows result as either positive or negative. Quantitative immunity shows results as a measure of the amount of antibody present. It is required that students submit a lab report with a quantitative value.
    • Alternatively, one of the following must apply:
      • Learners may be in the process of completing their initial series or their second series.
      • Learners may decline (please be aware that this may limit your ability to participate in certain clinical rotations).
    • For more information on Hepatitis B requirements, visit the Association of American Medical Colleges (AAMC) Hep B FAQs.

TB attestation

Students should be prepared to show documentation of two negative skin tests. The first TB skin test needs to be within 15 months of start date. The second TB skin test needs to be within three months of start date. TB skin tests must be at least seven days apart. An IGRA blood test does not substitute for skin test requirement.

For students with a history of a prior positive TB skin test, a blood test is required. If a blood test is positive, a chest X-ray within the past 12 months is required.

Minnesota background study

A Minnesota background study is required by the Minnesota Department of Human Services (DHS) in order to work with patients directly. This can be completed prior to arrival on campus or within first seven days on campus.

Drug screen

Appointment at Mayo Clinic College of Medicine and Science is contingent upon successful completion of a drug screen. 

Transfer student policy

Mayo Clinic Alix School of Medicine does not accept requests for transfer from medical school students either currently or previously enrolled in another medical school program, international or domestic.

The only pathway to matriculation at Mayo Clinic Alix School of Medicine is through application to the American Medical College Application Service.

Due to Mayo Clinic Alix School of Medicine's unique curriculum that integrates basic and clinical science instruction into each curricular year, it is unlikely that students requesting transfer would have a fully compatible educational experience. In addition, our small class size limits the opportunity for available space.

Acceptance criteria

The committee considers these factors when selecting students:

  • Academic performance
  • MCAT score/percentile
  • GPA: GPA is just one of several factors taken into consideration during the application review process. There is not a minimum GPA requirement for admission to Mayo Clinic Alix School of Medicine. 
  • Depth and breadth of all experiences, including community and volunteer service, leadership and research, exposure to and exploration of medicine, artistic and athletic endeavors, and work experiences
  • Personal statement
  • Letters of recommendation

2019 admissions and acceptance statistics

Learn more about the 2019 admissions statistics and acceptance rate for the M.D. Program and the Medical Scientist Training Program (M.D.-Ph.D.).

Applications received: 7,265

  • Male: 3,901
  • Female: 3,353
  • Other: 11

On-campus interviews: 811

Acceptances issued: 172

New M.D. matriculates: 102

  • Male: 50
  • Female: 52

GPA and MCAT scores

  • Median cumulative GPA: 3.92
  • Median MCAT score: 520 (98th percentile)

2019 incoming class profile

  • 46 M.D. students for the four-year Minnesota campus
  • 50 M.D. students for the four-year Arizona campus
  • 23% underrepresented in medicine (relative to their numbers in the general population)