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Clinical and Translational Science Track

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Research focus

across the translational spectrum from discovery to implementation

4.3 years

average amount of time to Ph.D. degree

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Guaranteed 5-year internal fellowship

includes full tuition, stipend and benefits

Moving new biomedical discoveries into clinical use as new treatments and cures takes considerable time and resources. A translational scientist is at the forefront of this work, teaming with an integrated group of experts focused on taking knowledge gained through research and translating it for use in health care settings. This bench-to-bedside effort is essential to bridging the gap between basic science and patient care.

The Clinical and Translational Science (CTS) Track within the Ph.D. Program at Mayo Clinic Graduate School of Biomedical Science is built upon Mayo Clinic's extensive interdisciplinary research and medical environment. It prepares you to lead the biomedical research teams of the future that will rapidly translate discoveries to new treatments and change the paradigms of how we conduct biomedical research.

As a graduate of this program, you’ll be able to conduct research leading to meaningful scientific contributions. In addition, you’ll be prepared to change and improve how biomedical research is conceptualized and implemented.

The Clinical and Translational Science Track allows students to personalize their studies in three areas of emphasis:

  • Population-based translational science
  • Patient-based translational science
  • Laboratory-based translational science

A great strength of the Mayo Clinic CTS track is its focus on providing mentored research experiences for each student. The pre-eminent physicians, scientists, and educators who comprise the faculty at Mayo Clinic are available as mentors or co-mentors for students in the track.

Curriculum

All doctoral students in the CTS track have a common core curriculum.  Depending on your area of concentration (laboratory-, patient- or population-based translational science), you’ll select your advanced courses from either track courses or graduate school courses in the basic science disciplines.

Year 1

  • Core required courses  
  • Track required courses  
  • Lab rotations  
    • Introduction to research projects and methodologies used in the laboratories of clinical/translational investigators
    • Completion of three research experiences or laboratory rotations, each lasting eight weeks
    • Selection of laboratory for thesis research

Year 2

  • Advanced elective courses (areas of interest)
  • Thesis research
    • Research gathering preliminary data for a thesis research project
    • Preparation of a thesis proposal in the format of a grant application
    • Selection of faculty for the oral qualifying exam committee, followed by defense of the research proposal in the oral exam (to be completed before the end of the fall quarter)
  • Written Comprehensive Examination

Years 3-5+

  • Oral Qualifying Examination (presentation of thesis proposal)
  • Ongoing workshops/seminars/journal clubs
  • Completion of thesis research and any remaining course requirements
  • Selection of your Graduate School Thesis Advisory Committee that will evaluate the proposed direction, specific aims, and experimental strategies of your project, as well as meet with you at least twice a year to discuss your research progress
  • Works-in-progress presentation of research project
  • Final Oral Examination (thesis defense)
Kevin Kelly

I chose the Clinical and Translational Science Track because of the flexibility of the program. Much of your coursework can be whichever topic helps you most for your research, and there are very few restrictions on the principal investigators you can work under. Also, because Mayo provides access to such unique patient populations, I’m able to use a lot of techniques that I wouldn’t be able to at a university or institution.

Kevin Kelly
Ph.D. student, Clinical and Translational Science Track

Alaa Koleilat

One thing that attracted me to the CTS Track is how supported I felt as a student and the opportunities we have to learn and grow. We’re encouraged to explore career options other than the traditional academic route. I’m interested in translational science, and there have been numerous examples in which discoveries happened at the bench and ended up as clinical trials here at Mayo.

Alaa Koleilat, Ph.D.
2020 graduate of the Ph.D. Program, Clinical and Translational Science Track

Photo of Josiane Joseph, MSTP student at Mayo Clinic

Mayo Clinic draws students and patients from all over the world, which creates a unique educational environment. It also emphasize patient needs, which shapes the way that students learn and interact with other professionals. The small class size and primary focus on biomedical sciences contributes to the welcoming, energetic and collaborative environment. The leaders of all the programs I am associated with are clearly invested in my success.

Josiane Joseph
M.D.-Ph.D. student, Clinical and Translational Science Track

2021

  • "BLOOM: Beta-lactam Optimization and Outcomes Management," Erin Barreto (Mentor: Andrew Rule, M.D.)
  • "Differentiating types of dementia using extracellular vesicles," Maria Esperanza Bregendahl (Mentor: Pam J. McLean, Ph.D.)
  • "Investigating Sulfatase 2 effects on the tumor microenvironment in hepatobiliary cancers," Tayla Brooks (Mentor: Lewis. R. Roberts, M.B., Ch.B., Ph.D.)
  • "Defining racial differences in hedgehog-associated breast cancer risk biomarkers in normal breast biopsies," Jennifer Cabezas (Mentor: Derek Radisky, Ph.D.)
  • "Cytokine Mediated Death and Survival in Multiple Myelom," Allison (Allie) Carr (Mentor: Adrian T. Ting, Ph.D.)
  • "Peripheral multi-omics biomarkers of Alzheimer’s and related phenotypes," Xuan Chen (Mentor: Nilufer Taner, M.D., Ph.D.)
  • "Pulmonary Hypertension Secondary to Left Heart Diseases," Ahmed Fayyaz (Mentor: Margaret M. Redfield, M.D.)
  • "Using focused ultrasound (FUS) to enhance the delivery of intravenous umbilical cord-derived mesenchymal stem cells (UCMSC) in chronic spinal cord injured rats," Abdul Karim (AK) Ghaith (Mentors: Mohamad Bydon M.D., and Anthony J. Windebank M.D.)
  • "The Role of the Endocannabinoid System in Systemic Stress Response in Zebrafish," Robin Heider (Mentor: Karl J. Clark, Ph.D.)
  • "Utilizing long-read sequencing to unravel the clinical heterogeneity in motor neuron diseases and undiagnosed genetic disorders," Angita (AJ) Jain (Mentor: Marka M. Van Blitterswijk, M.D., Ph.D.)
  • "Unraveling the Immunological Basis of Lobular Involution Stagnation in Breast Cancer Development," Jaida Lue (Mentor: Derek Radisky, Ph.D.)
  • "Artificial intelligence derived voice biomarkers for the detection and management of cardiovascular disease," Jaskanwal Deep (Jas) Sara (Mentor: Amir Lerman, M.D.)
  • "Characterization of Mitochondrial DNA variations, heteroplasmic levels, and deletion frequency in Pacbio’s continuous long reads," Ngan Tran (Mentor: Owen Ross, Ph.D.
  • "Unrefined: Hepatocellular carcinoma and hepatitis burden and potential interventions in x population," Caitlin VanLith (Mentor: Lewis. R. Roberts, M.B., Ch.B., Ph.D.)
  • "Data Independent Acquisition of Small Molecule Signatures to Characterize Inborn Errors of Metabolism," Rachel Wurth (Mentor: Devin Oglesbee, Ph.D.)

2020

  • "Developing Strategies to address health disparities for first generation regenerative medicine treatments," Mohamed (Mo) Addani (Mentor: Zubin Master, Ph.D.)
  • "Utility of Methylated DNA Markers for the Diagnosis of Malignant Pancreatic Biliary Strictures," Matthew Cooley (Mentor: Lewis. R. Roberts, M.B., Ch.B., Ph.D.)
  • "Electrical stimulation of hippocampus and amygdala modulates human ventral temporal cortex in distinct ways," Harvey Huang (Mentor: Dora Hermes, Miller Ph.D.)
  • "Senolytics and antifibrotic treatment for chronic spinal cord injury," Vagisha Kulsreshtha (Mentors: James Kirkland M.D., Ph.D., and Isobel A. Scarisbrick Ph.D.)
  • "HDAC1/OLIG2/STAT5 transcriptional complex facilitates GSC-mediated invasion and tumorigenesis," Auna’y Miller (Mentor: Nhan L. Tran, Ph.D.)
  • "Transcriptional adaptation as a possible mechanism underlying amyotrophic lateral sclerosis," Adriana (Adri) Morales Gomez (Mentor: Nathan Staff M.D., Ph.D.)
  • "Single Cell Landscape of Infiltrating Immune Cells in Cholangiocarcinoma," Hannah Stumpf (Mentor: Sumera I. Ilyas, M.B.B.S.)
  • "Developing a Value-Based Hybrid Care Model for Stroke Patients," Stephanie Zawada (Mentor: Bart M. Demaerschalk, M.D.)

2019

  • “Improving Facial Paralysis Surgical Outcomes: Targeting Facial Nerve Regeneration,” Marissa Suchyta (Mentor: Samir Mardini, M.D.)
  • “Regenerative Capabilities of Extracellular Vesicles in Myocarditis,” Danielle Beetler (Mentor: DeLisa Fairweather, Ph.D.)
  • “Machine Learning-Aided Biomarker Discovery and Precision Genomics for Gallbladder Cancer,” Linsey Jackson (Mentor: Lewis R. Roberts, M.B., Ch.B., Ph.D.)
  • “Pathway Discovery in Neurodegenerative Diseases by Integration of Multi-omics Data,” Yuhao (Harry) Min (Mentor: Nilufer Taner, M.D., Ph.D.)
  • “Investigating Uterine Fibroids in Women of Color: A Translational Approach,” Minerva Orellana (Mentors: Felicity T. Enders, Ph.D. and Elizabeth (Ebbie) A. Stewart, M.D.)
  • “Natural Language Processing Aided Discovery of Adverse Symptoms during Fertility Procedures,” Karen DSouza (Mentor: Megan A. Allyse, Ph.D.)

2018

  • “Understanding and Promoting Student Wellbeing Through Social-Emotional Behavioral Programming,” Catherine Knier (Mentor: Dr. Anthony J. Windebank, M.D, and Christopher K. Pierret, Ph.D.)
  • “Reducing the Burden of Hepatocellular Carcinoma Among Migrant Populations: Improving Prevention and Outcomes Through Disease Modeling,” Kenneth Valles (Mentor: Lewis R. Roberts, M.B., Ch.B., Ph.D.)
  • “Living Systematic Reviews and Guideline Updates in Areas with Rapidly Evolving Evidence,” Irbaz Bin Riaz (Mentor: M. Hassan Murad, M.D.)
  • “Sex Differences in Mitochondria During Acute cvb3 Myocarditis,” Damian Di Florio (Mentor: DeLisa Fairweather, Ph.D.)
  • “The Role of Convection-Enhanced Delivery for Diffuse Intrinsic Pontine Glioma,” Erica Power (Mentor: David J. Daniels, M.D., Ph.D)
  • “Subcutaneous Combination Biodevice for the Treatment of Type 1 Diabetes,” Ethan Law (Mentor: Quinn P. Peterson, Ph.D.)
  • “Technologies to Enable Closed-loop Neurochemical Control in Deep Brain Stimulation,” Aaron Rusheen (Mentor: Kendall H. Lee, M.D., Ph.D.)

2017

  • “Functional Validation in Unsolved Rare Disease Patients as a Method of Providing and Clarifying Diagnosis,” Brad Bowles (Mentor: Karl J. Clark, Ph.D. and Eric W. Klee, Ph.D.)
  • “The Role of Glypican-3 Isoforms in the Development of Chimeric Antigen Receptor T Cells for Liver Cancer Therapy,” Aarti Koluri (Mentor: Lewis R. Roberts, M.B., Ch.B., Ph.D.)
  • “Clinical Implementation of Tobacco Cessation Treatment among Cancer Patients,” Josh Ohde, Ph.D. (Mentor: David O. Warner, M.D.)
  • “Metabolic Abnormalities Associated with Disease Alter Progenitor Cell Function and Precede Tissue Deterioration,” Josiane Joseph (Mentor: Jason D. Doles, Ph.D.)
  • “Breast Cancer Mode of Detection Varies by Breast Density and Stage at Diagnosis in Population Based Cohort,” Susanna Basappa (Mentor: Lila J. Rutten, Ph.D.)

Your future

Many graduates of the Clinical and Translational Science Track choose to pursue postdoctoral training regardless of whether they intend to pursue careers in academia or industry. Other students choose to enter advanced training programs, such as genetics fellowships.

Meet the directors

Clinical and translational science is a rapidly developing area of science. Advances in technology and the way we approach and treat diseases or other conditions have set the stage for improved human health.

Our program combines the clinical and scientific resources of Mayo Clinic, where you’ll graduate with an understanding of how research is translated to health care, and ready to carry out research that accelerates medical discoveries into better health.

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Faculty

Browse a list of Clinical and Translational Science Track faculty members

Academics ▸ Biomedical Research Training ▸ Ph.D. Program ▸ Tracks ▸ Clinical and Translational Science

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